The mechanisms help explain issues such as why people traveling long distances over several time zones often suffer jet lag and they have wider implications for health such as increased risk for certain diseases.
“The three scientists’ discoveries explain how plants, animals and humans adapt their biological rhythm so that it is synchronized with the Earth’s revolutions,” the Nobel Assembly at Sweden’s Karolinska Institute said in a statement.
The laureates used fruit flies to isolate a gene that controls the normal daily biological rhythm and showed how this gene encoded a protein that accumulates in the cell during the night and degrades during the day.
“The clock regulates critical functions such as behavior, hormone levels, sleep, body temperature and metabolism,” the Assembly said on awarding the prize of 9 million Swedish crowns ($1.1 million).
Thomas Perlmann, secretary at the Karolinska Institute Nobel Committee, described the reaction of Rosbash when first informed of the award: “He was silent and then he said ‘you are kidding me’.”
Medicine is the first of the Nobel Prizes awarded each year. The prizes for achievements in science, literature and peace were created in accordance with the will of dynamite inventor and businessman Alfred Nobel and have been awarded since 1901.
Nobel medicine laureates have included scientific greats such as Alexander Fleming, the discoverer of penicillin, and Karl Landsteiner, whose identification of separate blood types opened the way to carrying out safe transfusions.
The prize has not been without controversy, especially with the benefit of hindsight, such as with 1948 award for the discovery of DDT, a chemical that helped battle epidemics but was later banned due to its harmful environmental impact.