Chattogram-bound Udayan Express from Sylhet and Dhaka-bound Turna Nishita from Chattogram collided at Mondobhag Railway Station around 3 am.
The identities of the deceased could not be known immediately.
Shayamal Kanti Das, officer-in-charge of Akhaura Railway Police Station, confirmed the news.
The injured were taken to the local hospital immediately after the incident.
Rail communication between Dhaka-Chattogram, Dhaka-Noakhali and Chattogram-Sylhet has been suspended following the accident.
Relief trains from Akhaura and Laksam railway junctions rushed to the spot and started rescue operation, Akhaura Railway Junction sources said.